Immunohistochemical Localization of Membrane and a - Granule Proteins in Human Megakaryocytes : Application to Plastic - Embedded Bone Marrow Biopsy Specimens
نویسندگان
چکیده
Using a new technique for antigen localization. we have demonstrated platelet proteins in megakaryocytes in plastic-embedded biopsy specimens of normal human bone marrow. In a series of 25 specimens. megakaryocytes showed labeling with antibodies to the integral membrane glycoproteins lIla. llb. and the lIb-Illa complex; granule membrane protein 140; and five alpha-granule matrix proteins: thrombospondin. factor VIII-related antigen. -
منابع مشابه
Immunohistochemical Localization of Membrane and a - Granule Proteins in Human Megakaryocytes : Application to Plastic - Embedded Bone Marrow Biopsy
Using a new technique for antigen localization. we have demonstrated platelet proteins in megakaryocytes in plastic-embedded biopsy specimens of normal human bone marrow. In a series of 25 specimens. megakaryocytes showed labeling with antibodies to the integral membrane glycoproteins lIla. llb. and the lIb-Illa complex; granule membrane protein 140; and five alpha-granule matrix proteins: thro...
متن کاملImmunohistochemical localization of membrane and alpha-granule proteins in human megakaryocytes: application to plastic-embedded bone marrow biopsy specimens.
Using a new technique for antigen localization, we have demonstrated platelet proteins in megakaryocytes in plastic-embedded biopsy specimens of normal human bone marrow. In a series of 25 specimens, megakaryocytes showed labeling with antibodies to the integral membrane glycoproteins IIIa, IIb, and the IIb-IIIa complex; granule membrane protein 140; and five alpha-granule matrix proteins: thro...
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متن کاملImmunohistochemical localization of membrane and alpha-granule proteins in plastic-embedded mouse bone marrow megakaryocytes and murine megakaryocyte colonies.
Using an immunoperoxidase technique that permits optimal antigen localization at the light microscope level, we have detected two platelet alpha-granule constituents and three platelet membrane glycoproteins in mouse bone marrow megakaryocytes and in murine megakaryocyte colonies grown in soft agar culture for three to seven days. Using polyclonal antibodies prepared against human platelet prot...
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Using an immunoperoxidase technique that permits optimal antigen localization at the light microscope level. we have detected two platelet a-granule constituents and three platelet membrane glycoproteins in mouse bone marrow megakaryocytes and in murine megakaryocyte colonies grown in soft agar culture for three to seven days. Using polyclonal antibodies prepared against human platelet proteins...
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